Adenosine & caffeine

Adenosine

• Adenosine itself is a neuromodulator and is believed to play a role in promoting sleep and suppressing arousal
• Our body produces adenosine in the brain when fatigue builds up
• Adenosine keeps accumulating while awake
• c.f., Adenosine recepter
• A pressure gauge in the brain that senses sleep pressure
• The more adenosine biomolecule sticks to it (= adenosine recepter), the higher the sleep pressure in the brain feels. 
• Caffeine disturbs the sleep pressure gauge
• Caffeine is a molecule similar in structure to adenosine, so it sticks to the adenosine receptor, but unlike adenosine, the receptor does not recognize it as a fatigue signal.
• Caffeine is only blocking the place where adenosine will attach.
• So, if caffeine accumulates and the receptors are saturated, does the sleep pressure gauge completely fail?
• Because caffeine is a xenobiotic substance, that is, a foreign substance that has entered the body, our body dispatches enzymes to break it down.
• around 5 fours
• The effects of caffeine vary greatly from person to person, that is, from genome to genome.